Type VI secretion: a beginner's guide.
作者： Lewis EH Bingle , Christopher M Bailey , Mark J Pallen
DOI: 10.1016/J.MIB.2008.01.006
关键词:
摘要: Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, ATPase ClpV, regulatory FHA domain and secreted VgrG Hcp proteins. clearly key virulence factor some important pathogenic bacteria has implicated in translocation potential effector into eukaryotic cells by at least one organism (Vibrio cholerae). However, type systems (T6SSs) are widespread nature not confined to known pathogens. In accordance with general rule expression tightly regulated, controlled both transcriptional post-transcriptional levels.
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