Antiangiogenic therapy: more promise and, yet again, more questions.

作者: Lee M. Ellis

DOI: 10.1200/JCO.2003.07.977

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参考文章(14)
Corazon D. Bucana, Yasuhiko Kitadai, Karen R. Cleary, Lee M. Ellis, Yutaka Takahashi, Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer Cancer Research. ,vol. 55, pp. 3964- 3968 ,(1995)
Bronislaw Pytowski, William O’Connor, Daniel J. Hicklin, Andrea Hooper, Yiwen Li, Karen King, Angel Santiago, Peter Bohlen, James Huber, Jay Overholser, Larry Witte, Marie Prewett, Antivascular Endothelial Growth Factor Receptor (Fetal Liver Kinase 1) Monoclonal Antibody Inhibits Tumor Angiogenesis and Growth of Several Mouse and Human Tumors Cancer Research. ,vol. 59, pp. 5209- 5218 ,(1999)
Jeanette M Wood, G Bold, Elizabeth Buchdunger, R Cozens, Stefano Ferrari, Jörg Frei, F Hofmann, Jürgen Mestan, H Mett, Terence O’Reilly, Elke Persohn, Johannes Rösel, Christian Schnell, David Stover, A Theuer, Harry Towbin, Fritz Wenger, K Woods-Cook, A Menrad, Gerhard Siemeister, M Schirner, Karl-Heinz Thierauch, Martin R Schneider, J Drevs, G Martiny-Baron, F Totzke, Dieter Marmé, PTK787/ZK 222584, a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration Cancer Research. ,vol. 60, pp. 2178- 2189 ,(2000)
Christiane J. Bruns, Wenbiao Liu, Darren W. Davis, Raymond M. Shaheen, David J. McConkey, Michael R. Wilson, Corazon D. Bucana, Daniel J. Hicklin, Lee M. Ellis, Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases Cancer. ,vol. 89, pp. 488- 499 ,(2000) , 10.1002/1097-0142(20000801)89:3<488::AID-CNCR3>3.0.CO;2-X
Han He, Virginia J. Venema, Xiaolin Gu, Richard C. Venema, Mario B. Marrero, Ruth B. Caldwell, Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin Through flk-1/KDR Activation of c-Src Journal of Biological Chemistry. ,vol. 274, pp. 25130- 25135 ,(1999) , 10.1074/JBC.274.35.25130
Fairooz Kabbinavar, Herbert I. Hurwitz, Louis Fehrenbacher, Neal J. Meropol, William F. Novotny, Grazyna Lieberman, Susan Griffing, Emily Bergsland, Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer Journal of Clinical Oncology. ,vol. 21, pp. 60- 65 ,(2003) , 10.1200/JCO.2003.10.066
Yutaka Takahashi, Susan L Tucker, Yasuhiko Kitadai, Aaryan N Koura, Corazon D Bucana, Karen R Cleary, Lee M Ellis, Vessel Counts and Expression of Vascular Endothelial Growth Factor as Prognostic Factors in Node-Negative Colon Cancer Archives of Surgery. ,vol. 132, pp. 541- 546 ,(1997) , 10.1001/ARCHSURG.1997.01430290087018
D. Senger, S. Galli, A. Dvorak, C. Perruzzi, V. Harvey, H. Dvorak, Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. ,vol. 219, pp. 983- 985 ,(1983) , 10.1126/SCIENCE.6823562
D Feng, J A Nagy, J Hipp, H F Dvorak, A M Dvorak, Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. Journal of Experimental Medicine. ,vol. 183, pp. 1981- 1986 ,(1996) , 10.1084/JEM.183.5.1981
Jane Kendrew, Laurent F Hennequin, Jon O Curwen, Donald J Ogilvie, Elaine S E Stokes, Michael Dukes, Alison L Bigley, Janet A Jackson, Graham H P Richmond, George A Graham, Rosemary Chester, Gareth D Hughes, Stephen R Wedge, Peter F Wadsworth, Helen L Musgrove, Sarah J Boffey, Andrew P Thomas, Paula J Valentine, Brenda Curry, ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration Cancer Research. ,vol. 62, pp. 4645- 4655 ,(2002)