Vessel Counts and Expression of Vascular Endothelial Growth Factor as Prognostic Factors in Node-Negative Colon Cancer

摘要: Background: The value of these prognostic factors was compared with that other clinicopathologic such as tumor grade, stage, mucin production, vascular invasion, perineural and lymphatic invasion. Objective: To determine whether the development distant recurrence in patients node-negative colon cancer could be predicted using vessel count endothelial growth factor (VEGF) expression. Design: Paraffin-embedded cancers were immunostained for VIII, VEGF, basic fibroblast factor, proliferating cell nuclear antigen; slides reviewed differentiation, presence vascular, lymphatic, and/or Setting: A large academic referral center where 27 operated on during 1988 1989. Main Outcome Measure: interval to recurrence. Results: Eight developed liver, lung, or lymph node metastases at a median 24 months. follow-up without 60 mean those who remained disease-free significantly fewer than suffered (20 vs 33, respectively). By univariate analysis, 3 factors—perineural count, VEGF expression—were correlated time multivariate only related differences Expression count. Conclusion: Vessel expression may useful predicting cancer. Arch Surg. 1997;132:541-546