Three New Single Nucleotide Polymorphisms Identified by a Genome-Wide Association Study in Korean Patients with Vitiligo

摘要: Genetic susceptibility is involved in the pathogenesis of vitiligo. Association studies with a whole genome-based approach instead single or few candidate genes may be useful for discovering new susceptible genes. Although etiology non-segmental and segmental types different, association between gene polymorphisms vitiligo has been reported, without defining type. Whole nucleotide (SNPs) were examined patients using Affymetrix GeneChip 500K mapping array, 10 functional classes significant SNPs selected. Genotyping data analysis selected was performed real-time PCR. Genotype allele frequencies significantly different both three target SNPs, DNAH5 (rs2277046), STRN3 (rs2273171), KIAA1005 (rs3213758). A stronger suggested mutation (rs3213758) type compared to vitiligo-related Korean patients, either