Motility-related Protein-1 (MRP-1/CD9) Reduction as a Factor of Poor Prognosis in Breast Cancer

摘要: The application of reliable markers is major importance for predicting the prognosis and instituting appropriate postsurgical treatment patients with breast cancer. Previously we showed that motility-related protein-1 (MRP-1), which identical to CD9, regulates cell motility, cultured tumor cells transfected MRP-1/CD9 cDNA have low motility metastatic potential. In addition, immunoblotting immunohistochemical study cancer revealed expression diminished as clinical stage a given advanced gene protein in lymph nodes was strikingly lower than primary cancers. this study, also investigated by analysis 143 freshly resected invasive ductal carcinomas breast: 52 tumors were I, 61 II, 30 III. Tumors classified positive when band intensity >30% compared control cells, ZR-75-30 evaluated antibody M31-15, those intensities 50% immunostained reduced had <50% M31-15. There 97 46 whose levels. disease-free rate former group higher latter (84.7% versus 51.4%, P<0.001). Similarly, overall survival significantly different between two groups (93.6% 69.6%, P=0.004). Multivariate Cox regression model indicated positively correlated better (P<0.001) estrogen receptor, tumor, node status. Our data suggest may be associated poor prognosis. It conceivable testing identify node-negative who are at high risk early disease recurrence.