Extensive liver metastasis of gastric cancer effectively treated by hepatic arterial infusion of 5-fluorouracil/cisplatin.

摘要: Most gastric cancer patients with jaundice caused by extensive liver metastasis show no tumor shrinkage response to systemic chemotherapy, while often showing severe adverse reactions. Their prognosis is very poor. We experienced two for whom hepatic arterial infusion (HAI) of 5-fluorouracil (5-FU) and cisplatin through an implantable port was effective treating metastasis. One patient had (serum bilirubin level before HAI therapy, 12.4 mg/dl) metachronous metastasis, prior chemotherapy 5-FU irinotecan not been effective. The other synchronous also exhibited 11.8 mg/dl). Both were treated cisplatin, 20 mg/m(2) 30 min on day 1, continuous intraarterial 5-FU, 300 mg/m(2), from 1 4 every week. metastatic tumors significantly reduced in volume the disappeared. They survived 27 weeks, respectively. A pharmacokinetic study conducted during period partial remission revealed that extraction ratios 0.89 0.024, respectively, suggesting a favorable first-pass effect 5-FU. Although our findings here suggest successful local control could improve deteriorated condition prolong survival some far advanced cancer, it essential pay much attention possible effects treatment.