Structural and biochemical investigation of bacteriophage N4-encoded RNA polymerases.
作者： Bryan Lenneman , Lucia Rothman-Denes
DOI: 10.3390/BIOM5020647
关键词:
摘要: Bacteriophage N4 regulates the temporal expression of its genome through activity three distinct RNA polymerases (RNAP). Expression early genes is carried out by a phage-encoded, virion-encapsidated RNAP (vRNAP) that injected into host at onset infection and transcribes genes. These encode components new transcriptional machinery (N4 RNAPII cofactors) responsible for synthesis middle RNAs. Both RNAPs belong to T7-like “single-subunit” family polymerases. Herein, we describe their mechanisms promoter recognition, regulation, roles in phage life cycle.
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