Plasma vascular endothelial but not fibroblast growth factor levels correlate with colorectal liver metastasis vascularity and volume
作者： M M Davies , S K Jonas , S Kaur , T G Allen-Mersh
关键词:
摘要: The extent to which plasma levels of angiogenic factors in healthy individuals and tumour volume-related variations colorectal cancer affect the accuracy circulating as predictors vascularity is unknown. We used enzyme-linked immunosorbant assay measure vascular endothelial growth factor (VEGF) basic fibroblast (bFGF) liver metastasis (CLM) patients, ‘no cancer’ controls. CLM volume was determined from computerized tomography scans, vessel count anti-endothelial antibody-stained biopsies. There a significant (P = 0.03) increase VEGF level 29 patients (median 180.3 pg ml−1, iqr 132.5–284.8 ml−1) compared with 19 controls 125.8 58.2–235.9 ml−1). were correlations between (r 0.66, P 0.03), 0.59, 0.53, 0.03). A upper quartile distribution had 70% sensitivity 75% specificity predicting an count. No relation identified bFGF levels. Plasma predicted vascularity, despite overlap normal variations. © 2000 Cancer Research Campaign
nature.com
sci-hub.se 参考文章(28)
G Sliutz, C Kainz, A Obermair, C Dadak, C Tempfer, Serum evaluation of basic FGF in breast cancer patients. Anticancer Research. ,vol. 15, pp. 2675- 2677 ,(1995)
Corazon D. Bucana, Yasuhiko Kitadai, Karen R. Cleary, Lee M. Ellis, Yutaka Takahashi, Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer Cancer Research. ,vol. 55, pp. 3964- 3968 ,(1995)
G Gasparini, A L Harris, Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. Journal of Clinical Oncology. ,vol. 13, pp. 765- 782 ,(1995) , 10.1200/JCO.1995.13.3.765
Claudio Basilico, David Moscatelli, The FGF family of growth factors and oncogenes. Advances in Cancer Research. ,vol. 59, pp. 115- 165 ,(1992) , 10.1016/S0065-230X(08)60305-X
Atsutake Okamoto, Shinichi Kondo, Koji Tsuruta, Takeo Mori, Takeshi Tominaga, Misao Yoshida, Tadaaki Taniguchi, Takaaki Ikeda, Masakazu Toi, Tomoe Matsumoto, Yutaka Yamamoto, Hideo Suzuki, Masatsugu Kitamura, Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clinical Cancer Research. ,vol. 2, pp. 821- 826 ,(1996)
LY Dirix, PB Vermeulen, A Pawinski, A Prové, I Benoy, C De Pooter, M Martin, AT Van Oosterom, Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. British Journal of Cancer. ,vol. 76, pp. 238- 243 ,(1997) , 10.1038/BJC.1997.368
Donald R. Senger, Livingston Van De Water, Lawrence F. Brown, Janice A. Nagy, Kiang-Teck Yeo, Tet-Kin Yeo, Brygida Berse, Robert W. Jackman, Ann M. Dvorak, Harold F. Dvorak, Vascular permeability factor (VPF, VEGF) in tumor biology Cancer and Metastasis Reviews. ,vol. 12, pp. 303- 324 ,(1993) , 10.1007/BF00665960
Kiyohide Fujimoto, Yuzo Ichimori, Tadao Kakizoe, Eigoro Okajima, Hiromi Sakamoto, Takashi Sugimura, Masaaki Terada, Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Biochemical and Biophysical Research Communications. ,vol. 180, pp. 386- 392 ,(1991) , 10.1016/S0006-291X(05)81305-1
David W Leung, George Cachianes, Wun-Jing Kuang, David V Goeddel, Napoleone Ferrara, None, Vascular endothelial growth factor is a secreted angiogenic mitogen Science. ,vol. 246, pp. 1306- 1309 ,(1989) , 10.1126/SCIENCE.2479986
Roselle J. Eisma, Jeffrey D. Spiro, Donald L. Kreutzer, Vascular endothelial growth factor expression in head and neck squamous cell carcinoma. American Journal of Surgery. ,vol. 174, pp. 513- 517 ,(1997) , 10.1016/S0002-9610(97)00166-9