Hematological and hemorheological Determinants of the Six-Minute Walk Test Performance in Children with Sickle Cell Anemia
作者： Xavier Waltz , Marc Romana , Marie-Dominique Hardy-Dessources , Yann Lamarre , Lydia Divialle-Doumdo
DOI: 10.1371/JOURNAL.PONE.0077830
关键词:
摘要: The six-minute walk test is a well-established submaximal exercise reflecting the functional status and clinical severity of sickle cell patients. aim present cross-sectional study was to investigate biological determinants performance in children with anemia. Hematological hemorheological parameters, pulmonary function were determined 42 anemia at steady state. during normalized for age, sex height expressed as percentage predicted distance. We showed that high level anemia, low fetal hemoglobin expression red blood deformability independent predictors performance. This describes first time impact rheology
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