Three-year changes in bone mineral density around the knee after a six-month course of oral alendronate following total knee arthroplasty. A prospective, randomized study.

摘要: Background: Bone mineral density decreases after total knee arthroplasty and is believed to affect prosthetic fixation. Treatment with alendronate has been shown improve short-term bone arthroplasty; however, the long-term effects of this therapy are unknown. The purpose study was evaluate a six-month course on arthroplasty. Methods: Sixty patients were randomly assigned receive either oral at dosage 10 mg/day for six months or no alendronate. in distal aspect femur proximal tibia measured preoperatively six, twelve, thirty-six arthroplasty. Results: Fifty-four (twenty-nine group twenty-five control group) completed study. showed significant increases compared controls (+4.8% –14.2%, respectively; p < 0.01) twelve (+1.6% –11.5%, 0.01). No difference detected between groups (–3.9% –12.2%, = 0.08). Similar trends changes also observed tibia. Conclusions: A initially increased arthroplasty, but noted months. effect may be limited discontinuation therapy. Level Evidence: Therapeutic Level I. See Instructions Authors complete description levels evidence.