Unusual early-stage pancreatic sarcomatoid carcinoma

摘要: Sarcomatoid carcinoma of the pancreas (SCP) is a very rare pathological type that usually has poor prognosis. Its pathogenesis not been elucidated. We herein report case an early-stage SCP involving successful treatment and good The patient was 48-year-old Chinese man with 5-mo history vague abdominal pain. Ultrasonography revealed 93 mm × 94 75 mass mixed echogenicity in tail pancreas. Laboratory test results were within normal range, exception obviously increased pretreatment neuron-specific enolase level. plasma transforming growth factor (TGF)β1 interleukin-11 levels according to enzyme-linked immunosorbent assay. Microscopically, excised tumor tissue comprised cancer cells mesenchymal cells. Immunohistochemical analysis positive for α-1-antichymotrypsin, pan-cytokeratin, cytokeratin 19, 8/18, vimentin negative CD68 lysozyme. pathogenetic mechanism this shows TGFβ1 may regulate epithelial-to-mesenchymal transition SCP. With early eradication systemic therapy, alive more than 3 years without recurrence or distant metastasis. This also first show