Carcinosarcoma of the Pancreas: Case Report With Comprehensive Literature Review.
作者： Dietrich A. Ruess , Claudia Kayser , Jakob Neubauer , Stefan Fichtner-Feigl , Ulrich T. Hopt
DOI: 10.1097/MPA.0000000000000904
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摘要: Carcinosarcomas are rare biphasic neoplasms with distinct malignant epithelial and mesenchymal components. Most commonly, carcinosarcomas arise in the uterus as mixed mullerian tumors, but also infrequently appear other organs such ovaries breast, prostate urinary tract, lungs, or gastrointestinal system, among others. Pancreatic exceedingly rare; only a few cases reported English literature. Their pathogenesis remains to be fully clarified. We present here case of pancreatic carcinosarcoma evidence for monoclonality via determination Kras mutational status after microdissection suggest common origin 2 tumor Comprehensive review available literature allows conclusion that most monoclonal seem have arisen from carcinoma metaplastic transformation 1 part subclone tumor, probably by epithelial-mesenchymal transition. All patients were treated surgery. Adjuvant therapy, if administered, consisted predominantly gemcitabine. Prognosis this neoplasm occurs similar even worse compared classic ductal adenocarcinoma. Despite lack evidence-based recommendations its treatment, resection should performed, possible.
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