Persistence of Human Herpesvirus 7 in Normal Tissues Detected by Expression of a Structural Antigen

摘要: Human herpesvirus 7 (HHV-7) infection in histologically normal human tissues was investigated by immunohistochemical detection of the 85-kDa tegument phosphoprotein (pp85) encoded U14 gene. So far, two cell types were recognized as sites HHV-7 vivo: CD4 + T lymphocytes, believed to be site latent infection, and epithelial cells salivary glands, productive viral shedding. Unexpectedly, expressing structural antigen detectable lungs, skin, mammary glands. Morphologically phenotypically, they distinct from lymphocytes. Liver, kidney, tonsils positive, although number HHV-7-positive low. Large intestine, spleen, brain negative. Different current notion state humans, results show that a variety harbor at late stage suggest causes persistent rather than true infection.