Establishment of a predominantly African-American cohort for the study of Alzheimer's disease: the South Carolina Alzheimer's disease clinical core.

摘要: Background/Aims: The recruitment of culturally diverse subject populations into research studies, particularly African-Americans (AA), has been the focus intense interest by many groups. Methods: In this paper, we present methodology utilized to create a predominantly AA cohort for longitudinal study risk factors in Alzheimer’s disease (AD). underlying strategy was that identifying geographically clinical venues within South Carolina (SC) where large numbers patients already come seek medical care. Results: This successful, although rates subjects (43.4%) still fell below those white (70.3%; p = 0.0025). Subject characteristics chose enroll were not substantially different from declined participate. demographic largely similar SC Alzheimer Disease Registry, population-based database. problems standardization and assessment across are also addressed. Conclusion: utilization sites minorities receive care is one practical solution problem minority participation research. Multi-site improve can be accomplished with acceptable inter-rater reliability.