Sex-Dependent Changes in Striatal Dopamine Transport in Preadolescent Rats Exposed Prenatally and/or Postnatally to Methamphetamine.

摘要: Methamphetamine (MA) is the most commonly used psychostimulant drug, chronic abuse of which leads to neurodegenerative changes in brain. The global use MA increasing, including pregnant women. Since can cross both placental and haematoencephalic barriers also present maternal milk, children chronically abused mothers are exposed prenatally as well postnatally. Women seem be more vulnerable some aspects than men. thought exert its effects among others via direct interactions with dopamine transporters (DATs) brain tissue. Sexual dimorphism DAT system could a base sex-dependent actions observed behavioural neurochemical studies. Possible sex differences DATs preadolescent offspring and/or postnatally have not yet been evaluated. We examined striatal synaptosomal (the activity density surface expressed total expression) male female Wistar rats (31–35-day old animals) (daily 5 mg/kg, s.c. during pregnancy lactation). To distinguish between specific nonspecific on DATs, we evaluated vitro lipophilic fluidity membranes isolated from young adult sexes. similar or (MA-mediated drop reserve pool but no alterations surface-expressed DATs). However, prenatal exposure evoked significant males postnatal females. A decrease was found only females sensitized exposure. applied increased rats. In summary, sensitive those same mechanism. combination increases risk dopaminergic deficits especially MA-mediated still enhanced disordering membranes.