Genetic analysis of hedgehog signalling in the Drosophila embryo.
作者： P. W. Ingham , A. J. Forbes , A. M. Taylor , Y. Nakano
DOI:
关键词:
摘要: The segment polarity genes play a fundamental role in the patterning of cells within individual body segments Drosophila embryo. Two these wingless (wg) and hedgehog (hh) encode proteins that enter secretory pathway both are thought to act by instructing fates neighbouring those which they expressed. Genetic analysis bas identified transcriptional activation wg as one targets hh activity: here we present evidence transduction hh-encoded signal is mediated activity four other genes, patched, fused, costal-2 cubitus interruptus. results our genetic epistatsis together with molecular structures products where known, suggest interactions leading from reception at cell membrane nucleus. We have also found transcription patched regulated same describe identification cis-acting upstream elements ptc unit mediate this regulation.
biologists.org参考文章(14)
Yves Grau, Pat Simpson, The segment polarity gene costal-2 in Drosophila. I. The organization of both primary and secondary embryonic fields may be affected. Developmental Biology. ,vol. 122, pp. 186- 200 ,(1987) , 10.1016/0012-1606(87)90344-7
A. Bejsovec, A. Martinez Arias, Roles of wingless in patterning the larval epidermis of Drosophila. Development. ,vol. 113, pp. 471- 485 ,(1991) , 10.1242/DEV.113.2.471
A. Hidalgo, P. Ingham, Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched Development. ,vol. 110, pp. 291- 301 ,(1990)
Jill Heemskerk, Stephen DiNardo, Richard Kostriken, Patrick H. O'Farrell, Multiple modes of engrailed regulation in the progression towards cell fate determination Nature. ,vol. 352, pp. 404- 410 ,(1991) , 10.1038/352404A0
Joan E. Hooper, Matthew P. Scott, The Drosophila patched gene encodes a putative membrane protein required for segmental patterning Cell. ,vol. 59, pp. 751- 765 ,(1989) , 10.1016/0092-8674(89)90021-4
Daniel St Johnston, Christiane Nüsslein-Volhard, The origin of pattern and polarity in the Drosophila embryo. Cell. ,vol. 68, pp. 201- 219 ,(1992) , 10.1016/0092-8674(92)90466-P
A.M. Taylor, Y. Nakano, J. Mohler, P.W. Ingham, Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo Mechanisms of Development. ,vol. 42, pp. 89- 96 ,(1993) , 10.1016/0925-4773(93)90101-3
Christiane Nüsslein-Volhard, Eric Wieschaus, Mutations affecting segment number and polarity in Drosophila Nature. ,vol. 287, pp. 795- 801 ,(1980) , 10.1038/287795A0
Tashiro Shigeki, Michiue Tatsuo, Higashijima Shin-ichi, Zenno Shuhei, Ishimaru Satoshi, Takahashi Fumitaka, Orihara Minako, Kojima Tetsuya, Saigo Kaoru, Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene. ,vol. 124, pp. 183- 189 ,(1993) , 10.1016/0378-1119(93)90392-G
Stephen DiNardo, Elizabeth Sher, Jill Heemskerk-Jongens, Judith A. Kassis, Patrick H. O'Farrell, Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis. Nature. ,vol. 332, pp. 604- 609 ,(1988) , 10.1038/332604A0