Helicobacter pylori pathogenicity and primary antimicrobial resistance in Northern Spain.

摘要: Background Helicobacter pylori infection is associated with chronic gastritis, ulcers and gastric cancer. Antimicrobial resistance has increased worldwide affecting the efficacy of current treatments. Most guidelines recommend implementation regional surveillance primary antibiotic H pylori. Only a fraction individuals infected develop diseases which are related to virulence factors bacteria. The aims study were determine antimicrobial rates know prevalence strains circulating in Southern Europe. Materials methods Susceptibility testing by Etest clarithromycin, levofloxacin, metronidazole, amoxicillin tetracycline was performed 102 isolates (99 naive patients). (cagA, vacA, oipA, babA dupA) evaluated from patients mild-disease symptoms 22 severe-disease symptoms. Results Primary 12.1% 13.1% 24.2% metronidazole 0% tetracycline. Combined clarithromycin levofloxacin 3% 4%. Prevalence mild- group 35.3% 81.8% for cagA, 20.6% 54.5% cagA/vacAs1m1, 94.1% 95.4% babA2, 78.4% 100% oipA 30.4% 18.2% dupA. Conclusions under 15% levofloxacin. carrying virulent genotype cagA/vacAs1m1 higher than 20% 54% symptom group.