Unravelling the effect of experimental pain on the corticomotor system using transcranial magnetic stimulation and electroencephalography

摘要: The interaction between pain and the motor system is well-known, with past studies showing that can alter corticomotor excitability have deleterious effects on learning. aim of this study was to better understand cortical mechanisms underlying system. Experimental induced 19 young healthy participants using capsaicin cream, applied middle volar part left forearm. effect brain activity assessed electroencephalography (EEG) transcranial magnetic stimulation (TMS), respectively. Compared baseline, resting state significantly increased after application in central cuneus (theta frequency), dorsolateral prefrontal cortex (alpha right insula (beta frequency). A pain-evoked increase primary (M1) also observed but only among who showed a reduction corticospinal output (as depicted by TMS recruitment curves). These further greater beta M1-cuneus connectivity than other participants. findings indicate increases M1 power are intimately tied changes system, provide evidence related alterations pain. differential pattern response our suggest variable from individual another; an observation could important clinical implications for rehabilitation professionals working patients.