Age-targeted chemotherapy for control of urinary schistosomiasis in endemic populations.

摘要: Severity of urinary tract morbidity increases with intensity and duration Schistosoma haematobium infection. We assessed the ability yearly drug therapy to control infection reduce S. haematobium-associated disease in children 5-21 years old an endemic area Kenya. In year I, resulted reduced prevalence (66% 22%, P < 0.001) (20 2 eggs/10 mL, urine), corresponding reductions hematuria (52% 19%, 0.001). There was not, however, a significant first-year effect on abnormalities detected by ultrasound. Repeat 3 regression hydronephrosis bladder (41% 6% prevalence, P< 0.001), further proteinuria. age-targeted associated decreased among young (< 5yr) entering into target age group. Two after discontinuation therapy, ultrasound remained suppressed, but began increase (to 33% 1989). Reinstitution annual 1989 1990 reversed this trends. conclude that oral provides effective strategy for due population basis, both through treated individuals, prevention untreated subjects.