Cisplatin and radiation in the treatment of tumors of the central nervous system: pharmacological considerations and results of early studies

摘要: Abstract Purpose: To review the human central nervous system pharmacology of cisplatin, factors that affect cisplatin uptake in tumors, and use alone with radiation for treatment primary brain tumors. Methods Materials: The authors their own prior published unpublished experience data by other groups on above issues. Results: Cisplatin is one most active chemotherapy drugs available solid It synergistic several agents, including radiation. While it attains only low concentrations normal system, plasma-tissue transfer constants intracerebral tumors are comparable to those extracerebral Tumor type appears be a more important determinant platinum concentration than tumor location, gliomas do achieve lower or excracerebral Several have also been identified correlate achieved combination does some degree efficacy against combining cranial irradiation has generally not resulted any substantial improvement outcome date, although individual studies somewhat encouraging. New approaches currently under investigation. Conclusion: Human provide rationale vitro suggest manipulations might potentially further augment concentrations. clinical combinations may value vs. metastases, while potentiates efficacy, no plus yet tested appeared superior alone.