Relation of arterial stiffness to diastolic dysfunction in hypertensive heart disease

摘要: Objectives: To examine the relation of arterial compliance to diastolic dysfunction in hypertensive patients with suspected heart failure (HF). Patients: 70 medically treated exertional dyspnoea (40 women, mean (SD) age 58 (8) years) and 15 normotensive controls. Main outcome measures: Mitral annular early velocity tissue Doppler imaging flow propagation were used as linear measures function. Arterial was determined by pulse pressure method. Results: According conventional echocardiography transmitral pulmonary venous flow, function classified normal 33 abnormal 37 patients. Of those dysfunction, 28 had mild (impaired relaxation) nine advanced (pseudonormal filling) dysfunction. highest controls (mean 1.32 (0.58) ml/mm Hg) became progressively lower hypertension (1.04 (0.37) Hg), impaired relaxation (0.89 (0.42) pseudonormal filling (0.80 (0.45) Hg, p  =  0.011). In inversely related (p 0.02), blood Conclusions: dyspnoea, is associated reduced compliance. an independent predictor disease should be considered a potential target for intervention HF.