The impact of sleep characteristics and epilepsy variables on memory performance in patients with focal seizures.

摘要: Disturbed sleep can negatively affect overnight memory retention as well new learning the subsequent day. In healthy participants, positive associations between performance and characteristics (e.g., time spent in slow-wave [SWS]) have been detected. a previous study, we found that SWS was much reduced patients with focal seizures, but when correlations complaints various were considered, only significant relationship to onset of rapid eye movement (REM) (i.e., REM latency). this investigated relationships sleep, epilepsy, objective variables. Twenty-five seizures had their tested while undergoing two-day ambulatory electroencephalography (EEG). The variables interest percentage (%SWS) latency. Epilepsy included presence (1) (2) interictal epileptiform discharges, and/or (3) hippocampal lesions site seizure origin (temporal vs extratemporal). Overnight (of autobiographical events, story, complex geometric figure) ability learn word list on day 2 measures memory. A correlation word-list %SWS during night. negative observed latency events. scores for story figure not related affected by activity. Story also worse temporal lobe epilepsy (TLE) than extratemporal (ETE). Those more impaired those without learning, events' retention, retention. When multiple contributing factors entered into regression analyses, be best predictor whereas lesion events story. These findings provide further evidence ways which particular are associated suggest treatment disturbances might helpful improving performance.