Effect of antioxidants on atherosclerotic plaque formation in balloon-denuded and irradiated hypercholesterolemic rabbits.

摘要: The oxidative modification of low-density lipoprotein (LDL) hypothesis implies that antioxidants should be effective in suppressing atherosclerosis. This study is designed to test the potential inhibit atherosclerotic plaque progression balloon-denuded and irradiated hypercholesterolemic rabbits. Rabbits were fed with a 1% cholesterol diet supplemented or without mixture (vitamin E, vitamin C, selenium, zinc, copper, manganese, N-acetylcysteine, glutamine). At 7 days both iliac arteries balloon denuded, 4 weeks later, I artery underwent endovascular irradiation (n = 12), while contralateral was sham treated 12). Four after irradiation, animals euthanized, fixed processed for histo- immunohistochemistry determining area, macrophage count, oxidized LDL-positive areas. Plasma antioxidant levels significantly higher diet. (thiobarbituric acid-reactive substances) arterial tissue LDL (immunorcactive specific antibody) as compared nonirradiated (0.69 ′ 0.09 31.05 4.21 versus 0.24 0.04 18.42 4.62, P < 0.001 0.05), partially lowered (0.35 0.14 25.41 4.82, 0.01). Plaque area 175% greater than (P 0.05). Antioxidant supplementation resulted 50% decrease control animals. Antioxidants reduced cholesterol-induced radiation-enhanced circulating levels, resulting plaque.