Therapy Control in Oncology by Circulating Nucleosomes

摘要: The courses of circulating nucleosomes in the serum patients with various solid tumors correlate clinical outcome after chemo- and radiotherapy. Already during initial phase treatment they showed considerable alterations consisting a rapid increase followed by decrease first therapeutic week. Among advanced lung cancer undergoing chemotherapy, those who responded to therapy exhibited less pronounced increases more complete decreases compared insufficient response. In addition, response was correlated stronger precyclic baseline values from cycle 1 2 3. Thus, are valuable tool for early prediction efficacy can help modulate strategies on an individual basis.