Comparative influences of different PB-type and 3-MC-type polychlorinated biphenyl-induced phenotypes on cytocidal hepatotoxicity of bromobenzene and acetaminophen.
作者： M.A. Hayes , E. Roberts , M.W. Roomi , S.H. Safe , E. Farber
DOI: 10.1016/0041-008X(84)90035-8
关键词:
摘要: The influences of in vivo treatment with two pure PCB congeners, 2,2',4,4',5,5'-hexachlorobiphenyl (HCBP) and 3,3',4,4'-tetrachlorobiphenyl (TCBP), on the lethal cytotoxicity bromobenzene acetaminophen were examined short-term primary cultures isolated rat hepatocytes. Lethal injury was measured by release lactate dehydrogenase (LDH) into culture medium after 20 hr exposure to hepatotoxins. HCBP, a PB-type inducer cytochrome P-450, resembled phenobarbitone (PB) its ability increase susceptibility hepatocytes (0.5 1.6 mM) (1 16 mM). This induced sensitivity consistently inhibited SKF-525-A (10 microM) but not alpha-naphthoflavone (ANF, 10 culture. 3,3',4,4'-TCPB, 3-MC-type 3-methylcholanthrene (3-MC) inability induce bromobenzene. TCBP 3-MC each increased (20- 30-fold) mechanism substantially inhibitable ANF SKF-525-A. These results demonstrate that categorizing isomers congeners groups according their different induction capabilities is predictive for modulate acute hepatocellular necrosis acetaminophen.
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