Expression of the p185 encoded by HER2 oncogene in normal and transformed human tissues.

摘要: The human homolog of the rat neu oncogene, HER2 (also termed c-erbB2) has been demonstrated in amplified form breast tumors with poor prognosis. Although amplification gene correlates expression a 185-kDa transmembrane glycoprotein, no extensive information is available regarding extent tissue and tumor specificity this product. We have addressed issue by immunohistochemically evaluating p185 normal various using monoclonal antibodies (MAbs) to distinct epitopes its extracellular domain. No detectable levels were found fetal tissues analyzed, exception renal tubules 2 out 3 specimens tested intestinal epithelium. In adult tissues, glycoprotein restricted number cell types, being heterogeneous among individuals histotypes. Among neoplasms assayed was expressed 46% primary cancers, 28% ovarian 30% colon rectum malignancies. male adenocarcinomas p185-positive. A large other revealed only low incidence p185. metastatic homogeneously multiple autologous lesions almost invariably (80%) lesion correlated that deriving metastases. Our findings indicate represents marker clinical relevance cancer. Whether holds true for malignancies remains be explored.