Creating 3D physical models to probe student understanding of macromolecular structure

摘要: The high degree of complexity macromolecular structure is extremely difficult for students to process. Students struggle translate the simplified two-dimensional representations commonly used in biochemistry instruction three-dimensional aspects crucial understanding structure-property relationships. We designed four different physical models address student electrostatics and noncovalent interactions their relationship structure. In this study, we have tested these classroom settings determine if are effective engaging at an appropriate level difficulty focusing attention on principles electrostatic attractions. This article describes how create unique targeted areas related structure: protein secondary structure, tertiary membrane solubility, DNA also provide evidence that merits use based analysis assembled a behavioral assessment enrolled introductory course. By providing with can be physically manipulated, barriers complex structures lowered focus shifted addressing foundational concepts behind properties. © 2017 by International Union Biochemistry Molecular Biology, 45(6):491-500, 2017.