Regulation of luteal cell big stanniocalcin production and secretion.

摘要: In mammals, the ovaries have highest levels of stanniocalcin (STC) gene expression, most or all which is confined to androgen-producing thecal-interstitial cells (TICs). Ovarian TICs also synthesize a different STC that consists three high molecular weight species collectively known as big STC. Upon release in response LH stimulation, TIC-derived sequestered locally by target cells, particularly steroidogenic corpus luteum, via receptor-mediated process. Although there little no expression luteal vivo setting, this report describes how turned on, mRNA becomes readily detectable, and secreted when bovine are cultured vitro. secretion were both positively regulated activation adenylate cyclase/protein kinase A signaling pathway (forskolin 8-bromo-cAMP). However, prostaglandin E2 was only natural cell ligand capable replicating effects ...