RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

摘要: The binding of RB to MDM2 is shown be essential for overcome both the antiapoptotic function and MDM2-dependent degradation p53. RB-MDM2 interaction does not prevent from inhibiting p53-dependent transcription, but complex still binds Since specifically rescues apoptotic transcriptional activity p53 negative regulation by MDM2, transactivation wild-type required However, an RB-MDM2-p53 trimeric active in p53-mediated transrepression. These data link directly two tumor suppressor proteins demonstrate a novel role regulating