Altered retinoblastoma and p53 protein status in non-small cell carcinoma of the lung: potential synergistic effects on prognosis.
作者： Hong Ji Xu , William F. Benedict , Shi Xue Hu , Philip T. Cagle , Jian Li
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摘要: Routinely processed pathological specimens from 119 patients with stage I and II adenocarcinomas or squamous cell carcinomas were examined by immunohistochemical analysis for altered retinoblastoma (RB) and/or p53 protein expression. Absent RB nuclear staining (RB-) indicating loss of function occurred in 19 (16%) the cases studied, whereas expression a putative mutant (p53(+)) was found 54 (45%) tumors. The median survival 39 versus 12 months RB+ RB- tumors, respectively (P = 0.05 log rank analysis). Similarly, 41 whose tumors had no (p53(-)) compared 24 individuals (+) 0.01). These differences survival, however, not statistically significant multivariate analysis. Nevertheless, RB-/p53(+) significantly shorter (12 months) than those RB+/p53(-) (41 months), as determined both analyses 0.005 0.03, respectively). In addition, 66 large all stages examined. Again, more difference (48 8 between 0. 006). results suggest that status might be used synergistically prognostic factors subset non-small lung carcinomas.
aacrjournals.org参考文章(22)
Piantadosi S, Figlin Ra, Holmes Ec, Koga H, Reissmann Pt, Takahashi R, Slamon Dj, Cordon-Cardo C, Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer Oncogene. ,vol. 8, pp. 1913- 1919 ,(1993)
T Mitsudomi, Seth M Steinberg, Marion M Nau, David Carbone, Domenico D'Amico, Sara Bodner, Herbert K Oie, R Ilona Linnoila, James L Mulshine, John D Minna, None, p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. ,vol. 7, pp. 171- 180 ,(1992)
Steinberg Sm, Mulshine Jl, Linnoila Ri, Ebina M, Relationship of p53 Overexpression and Up-Regulation of Proliferating Cell Nuclear Antigen with the Clinical Course of Non-Small Cell Lung Cancer Cancer Research. ,vol. 54, pp. 2496- 2503 ,(1994)
Hong Ji Xu, William F. Benedict, George E. Moore, Shi Xue Hu, Philip T. Cagle, Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Research. ,vol. 51, pp. 2735- 2739 ,(1991)
Setsuo Hirohashi, Takao Sekiya, Richard Sachse, Yoshinori Murakami, Hong Ji Xu, Xue Zhang, William F. Benedict, Shi Xue Hu, Kazuo Yashima, Deletions of Chromosome 13q, Mutations in Retinoblastoma 1, and Retinoblastoma Protein State in Human Hepatocellular Carcinoma Cancer Research. ,vol. 54, pp. 4177- 4182 ,(1994)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
J S Lee, A Yoon, S K Kalapurakal, J Y Ro, J J Lee, N Tu, W N Hittelman, W K Hong, Expression of p53 oncoprotein in non-small-cell lung cancer: a favorable prognostic factor. Journal of Clinical Oncology. ,vol. 13, pp. 1893- 1903 ,(1995) , 10.1200/JCO.1995.13.8.1893
Hong‐Ji Xu, Paul Cairns, Shi‐Xue Hu, Margaret A Knowles, William F Benedict, None, Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression. International Journal of Cancer. ,vol. 53, pp. 781- 784 ,(1993) , 10.1002/IJC.2910530513
Joseph Geradts, Shi-Xue Hu, Clinton E. Lincoln, William F. Benedict, Hong-Ji Xu, Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies. International Journal of Cancer. ,vol. 58, pp. 161- 167 ,(1994) , 10.1002/IJC.2910580203
David P. Carbone, Tetsuya Mitsudomi, Itsuo Chiba, Steven Piantadosi, Valerie Rusch, Jan A. Nowak, Donald McIntire, Dennis Slamon, Adi Gazdar, John Minna, p53 Immunostaining Positivity Is Associated With Reduced Survival and Is Imperfectly Correlated With Gene Mutations in Resected Non-small Cell Lung Cancer: A Preliminary Report of LCSG 871 Chest. ,vol. 106, ,(1994) , 10.1378/CHEST.106.6_SUPPLEMENT.377S