Retinoblastoma protein expression and MIB‐1 correlate with survival of patients with malignant astrocytoma

摘要: BACKGROUND Regulatory coupling of cell proliferation and apoptosis is suggested by recent findings with regard to certain tumors, such as the finding tumor resistance anticancer therapy caused inhibition apoptosis. The processes leading appear be regulated a variety oncogenes suppressor genes. In current study, relation between expression retinoblastoma protein (pRB) was assessed in 50 primary anaplastic astrocytomas (AAs) 46 recurrent tumors same patients after macroscopic total surgical resection chemoradiotherapy. METHODS Apoptotic cells were identified situ 3'-end labeling technique. Proliferative potential, pRB expression, p53 evaluated immunohistochemically using anti-Ki-67 (MIB-1), anti-pRB, anti-p53 antibodies, respectively. prognostic value these biologic markers AA undergoing treatment also evaluated. RESULTS The mean apoptotic index (AI) 0.91 ± 0.70% for specimens obtained at initial surgery 2.32 1.71% those recurrence. There no apparent correlation AI MIB-1 staining (MI) AAs, whereas significantly higher MI observed negative cases than their positive counterparts. survival AAs showing high immunostaining shorter other cases. Neither size fraction nor correlated overall survival. CONCLUSIONS The clinical outcome may associated aberrant function increased proliferative activity rather an inability undergo Cancer 1997; 80:242-9. © 1997 American Society.