Synthesis of pegylated immunonanoparticles.

作者: Jean‐Christophe Olivier , Ramon Huertas , Hwa Jeong Lee , Frederic Calon , William M. Pardridge

DOI: 10.1023/A:1019842024814

关键词:

摘要: Purpose. This work describes the synthesis of pegylated immunonanoparticles by conjugation an anti-transferrin receptor monoclonal antibody (MAb) to maleimide-grafted nanoparticles prepared from poly(lactic acid) (PLA) and a bi-functional polyethyleneglycol (PEG).

参考文章(23)
William Walter Simons, The Sadtler handbook of proton NMR spectra Sadtler. ,(1978)
William M. Pardridge, Jörg Huwyler, Jing Yang, Receptor Mediated Delivery of Daunomycin Using Immunoliposomes: Pharmacokinetics and Tissue Distribution in the Rat Journal of Pharmacology and Experimental Therapeutics. ,vol. 282, pp. 1541- 1546 ,(1997)
P. Quellec, R. Gref, L. Perrin, E. Dellacherie, F. Sommer, J. M. Verbavatz, M. J. Alonso, Protein encapsulation within polyethylene glycol‐coated nanospheres. I. Physicochemical characterization Journal of Biomedical Materials Research. ,vol. 42, pp. 45- 54 ,(1998) , 10.1002/(SICI)1097-4636(199810)42:1<45::AID-JBM7>3.0.CO;2-O
W. M. Pardridge, R. J. Boado, Y. S. Kang, Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 5592- 5596 ,(1995) , 10.1073/PNAS.92.12.5592
J. Huwyler, D. Wu, W. M. Pardridge, Brain drug delivery of small molecules using immunoliposomes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 14164- 14169 ,(1996) , 10.1073/PNAS.93.24.14164
Kenji Yasugi, Teruo Nakamura, Yukio Nagasaki, Masao Kato, Kazunori Kataoka, Sugar-Installed Polymer Micelles: Synthesis and Micellization of Poly(ethylene glycol)−Poly(d,l-lactide) Block Copolymers Having Sugar Groups at the PEG Chain End Macromolecules. ,vol. 32, pp. 8024- 8032 ,(1999) , 10.1021/MA991066L
T. Verrecchia, G. Spenlehauer, D.V. Bazile, A. Murry-Brelier, Y. Archimbaud, M. Veillard, Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers Journal of Controlled Release. ,vol. 36, pp. 49- 61 ,(1995) , 10.1016/0168-3659(95)00053-B
Didier Bazile, Christian Prud'homme, Marie‐Theérèse Bassoullet, Michel Marlard, Gilles Spenlehauer, Michel Veillard, Stealth Me.PEG‐PLA nanoparticles avoid uptake by the mononuclear phagocytes system Journal of Pharmaceutical Sciences. ,vol. 84, pp. 493- 498 ,(1995) , 10.1002/JPS.2600840420
R Gref, Y Minamitake, M. Peracchia, V Trubetskoy, V Torchilin, R Langer, Biodegradable long-circulating polymeric nanospheres Science. ,vol. 263, pp. 1600- 1603 ,(1994) , 10.1126/SCIENCE.8128245
T Riley, T Govender, S Stolnik, C.D Xiong, M.C Garnett, L Illum, S.S Davis, COLLOIDAL STABILITY AND DRUG INCORPORATION ASPECTS OF MICELLAR-LIKE PLA-PEG NANOPARTICLES Colloids and Surfaces B: Biointerfaces. ,vol. 16, pp. 147- 159 ,(1999) , 10.1016/S0927-7765(99)00066-1