Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets.
作者： Thomas N Seyfried , Michael Kiebish , Purna Mukherjee , Jeremy Marsh , None
DOI: 10.1111/J.1528-1167.2008.01853.X
关键词:
摘要: Information is presented on the calorically restricted ketogenic diet (CRKD) as an alternative therapy for brain cancer. In contrast to normal neurons and glia, which evolved metabolize ketone bodies fuel glucose under energy-restricted conditions, tumor cells are largely glycolytic due mitochondrial defects have a reduced ability bodies. The CRKD effective in managing growth animal models patients, appears act through antiangiogenic, anti-inflammatory, proapoptotic mechanisms.
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