Impact of genomics on personalized cancer medicine.

摘要: Recent advances in tumor genetics and drug development have led to the generation of a wealth anticancer targeted therapies. A few recent examples indicate that these drugs are mainly, if not exclusively, active against tumors particular genotype can be identified by diagnostic test, usually detecting somatic alteration DNA. However, for majority therapies development, there still no clinical tools determine which patients most likely benefit or, alternatively, resistant de novo novel agents or combinations. Clin Cancer Res; 18(3); 612–8. ©2011 AACR .