Immunological regulation of experimental cutaneous leishmaniasis. 2. Studies with Biozzi high and low responder lines of mice.

摘要: SUMMARY Susceptibility to Leishmania tropica was studied in Biozzi‘high’(Ab/H) and‘low’(Ab/L) responder mice of Selections I and III which, although originally selected with heterologous erythrocytes Salmonella flagellar antigens respectively, both show non-specific separation antibody responses. Ab/H Sel rapidly develop large, ulcerated, progressive, non-healing lesions (occasionally desseminating fatally) accompanied by rising serum titres. Ab/L produce only small lesions, even the largest infecting dose, which heal after 2 months minimal Specific delayed-type hypersensitivity (DTH) levels found are normal equivalent. (Ab/H × Ab/L)F1 behave intermediately. A smaller inter-line difference is detectable lower doses. Both given high doses chronic disease. These results imply that spontaneous resolution cutaneous L. during immune phase independent humoral antibody. While great resistance slower development entirely consistent macrophage‘hyperactivity’characteristic line, attempts demonstrate this vitro comparisons infected peritoneal exudate cells have been inconclusive so far.