Implants of polyanionic collagen matrix in bone defects of ovariectomized rats

摘要: In recent years, there has been a great interest in the development of biomaterials that could be used repair bone defects. Collagen matrix (CM) advantage it can modified chemically to improve its mechanical properties. The aim present study was evaluate effect three-dimensional membranes native or anionic (submitted alkaline treatment for 48 96 h) collagen on consolidation osteoporosis fractures resulting from gonadal hormone alterations caused by ovariectomy rats subjected replacement therapy. animals received implants 4 months after and were sacrificed 8 weeks implantation into 4-mm wide defects created distal third femur with surgical bur. Macroscopic analysis revealed absence pathological implanted areas, suggesting material biocompatible. Microscopic showed lower amount ingrowth areas receiving membrane compared filled membranes. ovariectomized membranes, delay regeneration observed mainly not We conclude treated solution h presented better results terms ingrowth.