Decrease in the expression of a novel TGF β1-inducible and ras-recision gene, TSC-36, in human cancer cells

摘要: TSC-36, a TGF β1-inducible gene, encodes polypeptide that shows significant similarity to SPARC (secreted protein rich in cysteine), and follistatin, an activin-binding protein. The expression of the TSC-36 gene was reported be extinguished v-ras-transformed mouse fibroblastic cells, also found abrogated cells transformed with v-myc. level was, however, not affected v-src, v-abl, or v-raf. cDNA first isolated from recently its rat human homologues have been which show striking each other. In various tumor mRNA almost undetectable. detected organs, but highest lung. lung among on situ hybridization, transcript alveolar epithelium bronchial epithelium. These features suggest possible usage as one markers tumors.