Homocysteine, B Vitamins, and Cognitive Impairment

摘要: Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's disease. Prospectively, tHcy associated with cognitive decline, white matter damage, brain atrophy, neurofibrillary tangles, dementia. Most homocysteine-lowering trials folate vitamins B6 and/or B12 tested as protective agents against decline were poorly designed by including subjects unlikely to benefit during the trial period. In contrast, in high-risk subjects, which have taken into account baseline B vitamin status, show slowing of atrophy critical regions, results that are consistent modification disease process. Homocysteine may interact both factors factors, thereby identifying people at but also providing potential strategies early intervention. Public health steps slow should be promoted individuals who r...