Dual variable region antibody-like binding proteins having cross-over binding region orientation
作者： Danxi Li , Ercole Rao , Vincent Mikol , Christian Lange , Christian Beil
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摘要: The invention provides antibody-like binding proteins comprising four polypeptide chains that form antigen sites, wherein each pair of polypeptides forming an protein possesses dual variable domains having a cross-over orientation. also methods for making such antigen-like proteins.
google.com.ph 参考文章(55)
Rodney E. Langman, The Immune System: Evolutionary Principles Guide Our Understanding of This Complex Biological Defense System ,(1989)
Tariq Ghayur, JiJie Gu, Cross-over dual variable domain immunoglobulin constructs ,(2013)
Gunars Valkirs, Jeff Gray, Joe Buechler, Polyvalent display libraries ,(1997)
W.D. Mallender, E.W. Voss, Construction, expression, and activity of a bivalent bispecific single-chain antibody. Journal of Biological Chemistry. ,vol. 269, pp. 199- 206 ,(1994) , 10.1016/S0021-9258(17)42334-9
Kathy Miller, Gloria Meng, Jun Liu, Amy Hurst, Vanessa Hsei, Wai-Lee Wong, Rene Ekert, David Lawrence, Steven Sherwood, Laura DeForge, Jacques Gaudreault, Gilbert Keller, Mark Sliwkowski, Avi Ashkenazi, Leonard Presta, Design, Construction, and In Vitro Analyses of Multivalent Antibodies Journal of Immunology. ,vol. 170, pp. 4854- 4861 ,(2003) , 10.4049/JIMMUNOL.170.9.4854
M S Cole, J Y Tso, S A Kostelny, Formation of a bispecific antibody by the use of leucine zippers. Journal of Immunology. ,vol. 148, pp. 1547- 1553 ,(1992)
Paul James Davis, Steve Wilson, Cornelis Paul Erik van der Logt, Martine Elisa Verhoeyen, A bifunctional or bivalent antibody fragment analogue ,(1996)
Edmund A. Rossi, Chien-Hsing Chang, William John McBride, Polyvalent protein complex ,(2004)
Samuel Davis, Kara Louise Olson, Eric Smith, Douglas MacDonald, Readily isolated bispecific antibodies with native immunoglobulin format ,(2010)
Danxi Li, Ercole Rao, Anne Minnich, Florent C. Bender, Amirtha Naadimuthu, Lei Tang, Brian N. Swanson, Haixin Yu, Uses of a dual v region antibody-like protein ,(2012)