摘要: Septic shock is a major cause of death following trauma and persistent problem in surgical patients throughout the world. It characterised by hypotension vascular collapse, with failure organs within body. The role excessive nitric oxide (NO) production, cytokine-dependent induction inducible synthase (iNOS), development septic discussed. Emphasis placed upon signal-transduction process which iNOS induced NO cellular energy dysfunction abnormal function cardiovascular system liver during shock.
sussex.ac.uk
elsevier.com
sci-hub.se 参考文章(295)
P.J.R. Phizackerley, S.A. Al-Dabbagh, The estimation of nitrate and nitrite in saliva and urine. Analytical Biochemistry. ,vol. 131, pp. 242- 245 ,(1983) , 10.1016/0003-2697(83)90161-6
Emery A. Minnard, Inhibition of Nitric Oxide Synthesis Is Detrimental During Endotoxemia Archives of Surgery. ,vol. 129, pp. 142- 148 ,(1994) , 10.1001/ARCHSURG.1994.01420260038004
J F Dhainaut, M F Huyghebaert, J F Monsallier, G Lefevre, J Dall'Ava-Santucci, F Brunet, D Villemant, A Carli, D Raichvarg, Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation. ,vol. 75, pp. 533- 541 ,(1987) , 10.1161/01.CIR.75.3.533
Kurt Krejcy, Severin Schwarzacher, Gerhard Raberger, Distribution and metabolism of NG-nitro-L-arginine and NG-nitro-L-arginine methylester in canine blood in vitro Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 347, pp. 342- 345 ,(1993) , 10.1007/BF00167455
Mark Salter, Richard G. Knowles, Salvador Moncada, Widespread tissue distribution, species distribution and changes in activity of Ca2+
-dependent and Ca2+
-independent nitric oxide synthases FEBS Letters. ,vol. 291, pp. 145- 149 ,(1991) , 10.1016/0014-5793(91)81123-P
E. A. Elebute, H. B. Stoner, The grading of sepsis. British Journal of Surgery. ,vol. 70, pp. 29- 31 ,(2005) , 10.1002/BJS.1800700111
D J Stuehr, S S Gross, I Sakuma, R Levi, C F Nathan, Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. Journal of Experimental Medicine. ,vol. 169, pp. 1011- 1020 ,(1989) , 10.1084/JEM.169.3.1011
Michael A. Marletta, Poksyn S. Yoon, Radha Iyengar, Cynthia D. Leaf, John S. Wishnok, Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry. ,vol. 27, pp. 8706- 8711 ,(1988) , 10.1021/BI00424A003
Isabelle Carpentier, Wim Declercq, Nikolai L Malinin, David Wallach, Walter Fiers, Rudi Beyaert, TRAF2 plays a dual role in NF-κB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IκB kinase pathways FEBS Letters. ,vol. 425, pp. 195- 198 ,(1998) , 10.1016/S0014-5793(98)00226-9
Kazuki Ohta, Yukio Hirata, Taihei Imai, Kazuo Kanno, Toshiaki Emori, Masayoshi Shichiri, Fumiaki Marumo, Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line. Biochemical and Biophysical Research Communications. ,vol. 169, pp. 578- 584 ,(1990) , 10.1016/0006-291X(90)90370-3