Modest familial aggregation of eating disorders in restrictive anorexia nervosa with adolescent onset in a Romanian sample

摘要: The study of the familial psychopathology in relatives restrictive anorexia nervosa (AN) probands whose diagnosis was verified during a long-term follow-up aimed at determining behavioural phenotypes with which AN could share genetic liability. A total 185 first degree 68 patients adolescent onset followed up for 5 to 18 years and 198 normal women were investigated. DSM-III-R criteria used. lifetime rate clinical 1 % any eating disorders 2 female proband versus 0 control relatives. No case bulimia (BN) found heritability low (0.18) when only full-blown considered modest (0.36) also subthreshold added. There significantly higher rates anxiety (14.6 %) unipolar major depression (8.3 “schizo”-spectrum alcoholism (13.1 male compared controls. Restrictive might partial liability expressing emotional restraint anxiety. sex effect heterotypically affected relative on vulnerability suggested.