Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer.

摘要: Abstract Background . To elucidate the relationship between expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) tumor recurrence. Methods We used immunohistochemistry to examine four in 73 patients with stage I non-small cell lung cancer. Results Using Cox univariate analysis, we determined that angiolymphatic emboli non-well-differentiated cells were two significant conventional pathologic predictors recurrence, ErbB-1 ErbB-3 also predictors. Coexpression + , -3 or three more had a effect on cancer A stepwise multivariate proportional hazards regression analysis provided predictive model for Conclusions The present study shows tumor, overexpression is useful marker predicting confirmed increased proportion loss differentiation. correlation distant metastasis was good.