Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.

摘要: Abstract Obesity and adiposity greatly increase the risk for secondary conditions such as insulin resistance. Mice deficient in enzyme stearoyl-CoA desaturase-1 (SCD1) are lean protected from diet-induced obesity In order to determine effect of SCD1 deficiency on various mouse models obesity, we introduced a global deletion Scd1 gene into leptin-deficient ob/ob mice, leptin-resistant Agouti (Ay/a) high-fat diet-fed obese (DIO) mice. lowered body weight, adiposity, hepatic lipid accumulation, lipogenic expression all three models. However, glucose tolerance, insulin, leptin sensitivity were improved by only Ay/a DIO but not These data uncouple effects weight loss those suggest beneficial inhibition mice that express functional gene.