Expression of syndecan-1 is common in human lung cancers independent of expression of epidermal growth factor receptor.
作者： Eri Toyoshima , Yoshinobu Ohsaki , Yutaka Nishigaki , Yoshinori Fujimoto , Yutaka Kohgo
DOI: 10.1016/S0169-5002(00)00184-7
关键词:
摘要: Abstract In order to determine syndecan-1 expression in lung cancer, we examined 115 cancer specimens and 17 cell lines. Syndecan-1 was immunohistochemically stained with a polyclonal antibody paraffin-embedded specimens; 84 cases out of 97 non-small (NSCLC) eight 18 small (SCLC) were positively stained. Simultaneously, epidermal growth-factor receptor (EGFR) stained; 47 NSCLC one case SCLC No significant correlation shown between EGFR ( P =0.68). mRNA detectable 16 lines nine 17. Eight had as well mRNA. PR-39 (1 μM) 80 pM transforming growth factor-β 1 (TGF-β ), did not increase expressions five We concluded that syndecan-1; however, protein correlate survival time patients.
elsevier.com
sci-hub.se 参考文章(30)
Birgitta AGERBERTH, Jong-Youn LEE, Tomas BERGMAN, Mats CARLQUIST, Hans G. BOMAN, Viktor MUTT, Hans JORNVALL, Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. FEBS Journal. ,vol. 202, pp. 849- 854 ,(1991) , 10.1111/J.1432-1033.1991.TB16442.X
John T Gallagher, M Kato, M Bernfield, H Wang, Jeremy E Turnbull, Cell surface syndecan-1 on distinct cell types differs in fine structure and ligand binding of its heparan sulfate chains. Journal of Biological Chemistry. ,vol. 269, pp. 18881- 18890 ,(1994) , 10.1016/S0021-9258(17)32250-0
R.D. Sanderson, J.E. Turnbull, J.T. Gallagher, A.D. Lander, Fine structure of heparan sulfate regulates syndecan-1 function and cell behavior. Journal of Biological Chemistry. ,vol. 269, pp. 13100- 13106 ,(1994) , 10.1016/S0021-9258(17)36804-7
Keiko Ichihara-Tanaka, Tomomitsu Okamoto, Hidehiko Saito, Tetsuhito Kojima, Kenji Kadomatsu, Yutaka Tomoda, Toru Nakanishi, Takashi Muramatsu, Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine Journal of Biochemistry. ,vol. 121, pp. 197- 205 ,(1997)
Raymond J. MacDonald, Galvin H. Swift, Alan E. Przybyla, John M. Chirgwin, [20] Isolation of RNA using guanidinium salts Methods in Enzymology. ,vol. 152, pp. 219- 227 ,(1987) , 10.1016/0076-6879(87)52023-7
Hitoshi Niikura, Hironobu Sasano, Gen Matsunaga, Keiko Watanabe, Kiyoshi Ito, Shinji Sato, Akira Yajima, Prognostic value of epidermal growth factor receptor expression in endometrioid endometrial carcinoma Human Pathology. ,vol. 26, pp. 892- 896 ,(1995) , 10.1016/0046-8177(95)90013-6
U WAGNER, G SAUTER, H MOCH, H NOVOTNA, R EPPER, M MIHATSCH, F WALDMAN, Patterns of p53, erbB-2, and EGF-r expression in premalignant lesions of the urinary bladder Human Pathology. ,vol. 26, pp. 970- 978 ,(1995) , 10.1016/0046-8177(95)90086-1
Tania Roskams, Rita De Vos, Guido David, Boudewijn Van Damme, Valeer Desmet, Heparan sulphate proteoglycan expression in human primary liver tumours The Journal of Pathology. ,vol. 185, pp. 290- 297 ,(1998) , 10.1002/(SICI)1096-9896(199807)185:3<290::AID-PATH91>3.0.CO;2-I
Akinori Matsumoto, Minoru Ono, Yoshinori Fujimoto, Richard L. Gallo, Merton Bernfield, Yutaka Kohgo, Reduced expression of syndecan-1 in human hepatocellular carcinoma with high metastatic potential. International Journal of Cancer. ,vol. 74, pp. 482- 491 ,(1997) , 10.1002/(SICI)1097-0215(19971021)74:5<482::AID-IJC2>3.0.CO;2-#
Kris Nackaerts, Erik Verbeken, Georges Deneffe, Bernadette Vanderschueren, Maurits Demedts, Guido David, Heparan sulfate proteoglycan expression in human lung-cancer cells International Journal of Cancer. ,vol. 74, pp. 335- 345 ,(1997) , 10.1002/(SICI)1097-0215(19970620)74:3<335::AID-IJC18>3.0.CO;2-A