Disrupted in Schizophrenia 1 Interactome : evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
作者： L M Camargo , V Collura , J-C Rain , K Mizuguchi , H Hermjakob
关键词:
摘要: Disrupted in Schizophrenia 1 (DISC1) is a schizophrenia risk gene associated with cognitive deficits both schizophrenics and the normal ageing population. In this study, we have generated network of protein–protein interactions (PPIs) around DISC1. This has been achieved by utilising iterative yeast-two hybrid (Y2H) screens, combined detailed pathway functional analysis. so-called ‘DISC1 interactome’ contains many novel PPIs provides molecular framework to explore function The implicates DISC1 processes cytoskeletal stability organisation, intracellular transport cell-cycle/division. particular, looks PPI profile consistent that an essential synaptic protein, which fits well underlying pathology observed at level seen behaviourally schizophrenics. Utilising similar approach dysbindin (DTNBP1), second gene, show share common suggesting they may affect biological genes converge.
nature.com
sci-hub.se 参考文章(74)
Andreas Zanzoni, Luisa Montecchi-Palazzi, Michele Quondam, Gabriele Ausiello, Manuela Helmer-Citterich, Gianni Cesareni, MINT: a Molecular INTeraction database. FEBS Letters. ,vol. 513, pp. 135- 140 ,(2002) , 10.1016/S0014-5793(01)03293-8
Mark Renato Stefani, Bita Moghaddam, Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia Biological Psychiatry. ,vol. 57, pp. 433- 436 ,(2005) , 10.1016/J.BIOPSYCH.2004.11.031
C. von Mering, E. M. Zdobnov, S. Tsoka, F. D. Ciccarelli, J. B. Pereira-Leal, C. A. Ouzounis, P. Bork, Genome evolution reveals biochemical networks and functional modules. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 15428- 15433 ,(2003) , 10.1073/PNAS.2136809100
Atsushi Kamiya, Ken-ichiro Kubo, Toshifumi Tomoda, Manabu Takaki, Richard Youn, Yuji Ozeki, Naoya Sawamura, Una Park, Chikako Kudo, Masako Okawa, Christopher A. Ross, Mary E. Hatten, Kazunori Nakajima, Akira Sawa, A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nature Cell Biology. ,vol. 7, pp. 1067- 1078 ,(2005) , 10.1038/NCB1328
Mary B. Kennedy, Holly C. Beale, Holly J. Carlisle, Lorraine R. Washburn, Integration of biochemical signalling in spines Nature Reviews Neuroscience. ,vol. 6, pp. 423- 434 ,(2005) , 10.1038/NRN1685
Zheng Li, Morgan Sheng, Some assembly required: the development of neuronal synapses Nature Reviews Molecular Cell Biology. ,vol. 4, pp. 833- 841 ,(2003) , 10.1038/NRM1242
N.J Brandon, E.J Handford, I Schurov, J.-C Rain, M Pelling, B Duran-Jimeniz, L.M Camargo, K.R Oliver, D Beher, M.S Shearman, P.J Whiting, Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders. Molecular and Cellular Neuroscience. ,vol. 25, pp. 42- 55 ,(2004) , 10.1016/J.MCN.2003.09.009
P.A. Thomson, S.E. Harris, J.M. Starr, L.J. Whalley, D.J. Porteous, I.J. Deary, Association between genotype at an exonic SNP in DISC1 and normal cognitive aging Neuroscience Letters. ,vol. 389, pp. 41- 45 ,(2005) , 10.1016/J.NEULET.2005.07.004
N.J. Brandon, I. Schurov, L.M. Camargo, E.J. Handford, B. Duran-Jimeniz, P. Hunt, J.K. Millar, D.J. Porteous, M.S. Shearman, P.J. Whiting, Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site Molecular and Cellular Neuroscience. ,vol. 28, pp. 613- 624 ,(2005) , 10.1016/J.MCN.2004.11.003
Erzsébet Ravasz, Anna Lisa Somera, Dale A Mongru, Zoltán N Oltvai, A-L Barabási, Hierarchical Organization of Modularity in Metabolic Networks Science. ,vol. 297, pp. 1551- 1555 ,(2002) , 10.1126/SCIENCE.1073374