Ectopic lipid storage and insulin resistance: a harmful relationship

作者: J. Borén , M.-R. Taskinen , S.-O. Olofsson , M. Levin

DOI: 10.1111/JOIM.12071

关键词:

摘要: … newly assembled lipid droplets (0.1–0.2 μm in diameter and … appear to have a central role in the development of insulin resistance… a link between lipid droplets and insulin resistance 24. …

参考文章(165)
K Boström, M Wettesten, J Borén, G Bondjers, O Wiklund, S O Olofsson, Pulse-chase studies of the synthesis and intracellular transport of apolipoprotein B-100 in Hep G2 cells. Journal of Biological Chemistry. ,vol. 261, pp. 13800- 13806 ,(1986) , 10.1016/S0021-9258(18)67090-5
Javier Martinez-Botas, John B. Anderson, Darin Tessier, Alexandre Lapillonne, Benny Hung-Junn Chang, Michael J. Quast, David Gorenstein, Kuang-Hua Chen, Lawrence Chan, Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice Nature Genetics. ,vol. 26, pp. 474- 479 ,(2000) , 10.1038/82630
J Borén, L Graham, M Wettesten, J Scott, A White, S.O. Olofsson, The assembly and secretion of ApoB 100-containing lipoproteins in Hep G2 cells. ApoB 100 is cotranslationally integrated into lipoproteins. Journal of Biological Chemistry. ,vol. 267, pp. 9858- 9867 ,(1992) , 10.1016/S0021-9258(19)50173-9
You-Guo Niu, Rhys D. Evans, Myocardial metabolism of triacylglycerol-rich lipoproteins in type 2 diabetes. The Journal of Physiology. ,vol. 587, pp. 3301- 3315 ,(2009) , 10.1113/JPHYSIOL.2009.173542
Edgar E. Kooijman, Vladimir Chupin, Ben de Kruijff, Koert N. J. Burger, Modulation of Membrane Curvature by Phosphatidic Acid and Lysophosphatidic Acid Traffic. ,vol. 4, pp. 162- 174 ,(2003) , 10.1034/J.1600-0854.2003.00086.X
Ole Torffvit, Carl-David Agardh, The prognosis for type 2 diabetic patients with heart disease. A 10-year observation study of 385 patients. Journal of Diabetes and Its Complications. ,vol. 14, pp. 301- 306 ,(2000) , 10.1016/S1056-8727(00)00117-3
Maureen T Timlin, Elizabeth J Parks, Temporal pattern of de novo lipogenesis in the postprandial state in healthy men The American Journal of Clinical Nutrition. ,vol. 81, pp. 35- 42 ,(2005) , 10.1093/AJCN/81.1.35
C. Londos, D. L. Brasaemle, J. Gruia-Gray, D. A. Servetnick, C. J. Schultz, D. M. Levin, A. R. Kimmel, Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells Biochemical Society Transactions. ,vol. 23, pp. 611- 615 ,(1995) , 10.1042/BST0230611