Glipizide suppresses embryonic vasculogenesis and angiogenesis through targeting natriuretic peptide receptor A

摘要: Glipizide, a second-generation sulfonylurea, has been widely used for the treatment of type 2 diabetes. However, it is controversial whether or not glipizide would affect angiogenesis vasculogenesis. In present study, we early chick embryo model to investigate effect on and vasculogenesis, which are two major processes embryonic vasculature formation as well tumor neovascularization. We found that Glipizide suppressed both in yolk-sac membrane (YSM) blood island during developmental did either process epithelial mesenchymal transition (EMT) mesoderm cell migration. addition, interfere with separation smooth muscle progenitors from hemangioblasts. Moreover, natriuretic peptide receptor A (NPRA) identified putative target glipizide׳s inhibitory When NPRA was overexpressed activated, reduced. signaling may play crucial role vasculogenesis development.