Binding of plasma proteins to titanium dioxide nanotubes with different diameters.

摘要: Titanium and titanium alloys are considered to be one of the most applicable materials in medical devices because their suitable properties, importantly high corrosion resistance specific combination strength with biocompatibility. In order improve biocompatibility surfaces, current report initially focuses on specifying topography dioxide (TiO2) nanotubes (NTs) by electrochemical anodization. The zeta potential (ζ-potential) NTs showed a negative value confirmed agreement between measured theoretically predicted dependence ζ-potential salt concentration, whereby absolute diminished increasing concentrations. We investigated binding various plasma proteins different sizes charges using bicinchoninic acid assay immunofluorescence microscopy. Results effective comparatively higher protein 100 nm diameters (compared 50 or 15 nm). also dose-dependent effect serum amyloid A NTs. These results theoretical calculations total available surface area for indicate that largest (also considering NT lengths) is NTs, decreasing investigations will have an impact ability biomedical body leading increased durability devices.