Induction of E6/E7 Expression in Cottontail Rabbit Papillomavirus Latency Following UV Activation

摘要: Latent human papillomavirus (HPV) infections are widespread in the genital and respiratory tracts a source of recurrent disease. This study used cottontail rabbit (CRPV) model to determine presence E1, E6, E7 transcripts latent infection temporal change following UV activation. We found E1 all latently infected sites but no detectable E6 transcripts, consistent with our earlier studies HPV6/11 latency. These results suggest that this transcription pattern is broadly characteristic infections. E6/E7 were within 1 week irradiation, maximal induction (approximately 40% sites) at 2 weeks postirradiation. Papillomas induced approximately 26% irradiated after 3- 5-week lag. Sites did not form papillomas by 3 months irradiation CRPV DNA positive RNA negative. Thus, only subset can be express papillomas. propose molecular processes regulating