Circulating tumor-derived DNA may permit the early diagnosis of head and neck squamous cell carcinomas
作者： Diana Noronha Nunes , Luiz Paulo Kowalski , Andrew J.G. Simpson
DOI: 10.1002/1097-0215(200102)9999:9999<::AID-IJC1176>3.0.CO;2-C
关键词:
摘要: A series of eight microsatellite loci were assayed for both loss heterozygosity and new mutated alleles in 91 head neck squamous cell carcinomas. In 58 cases, alterations detected used as markers assaying the presence circulating tumor-derived DNA patients' plasma. This was unambiguously 17 cases. The probability detecting independent tumor stage found to be present even some individuals with I tumors. such DNA, however, could not correlated disease outcome or other significant clinical parameters, suggesting that it has no prognostic significance. results indicate a means early diagnosis
sci-hub.se 参考文章(18)
Pierre Laurent-Puig, Florence Coulet, Daniel Brasnu, Arnauld Cabelguenne, Philippe Beaune, Helene Blons, Thierry Lecomte, Jessica Zucman, Olivier Laccourreye, Detection of plasma tumor DNA in head and neck squamous cell carcinoma by microsatellite typing and p53 mutation analysis. Cancer Research. ,vol. 60, pp. 707- 711 ,(2000)
Felix Bonilla, Pilar España, Mariano Provencio, Gemma Dominguez, Jose M. Silva, Jose M. Garcia, Santiago San Martin, Maria J. Villanueva, Fatima Navarro, Rocio Gonzalez, Presence of tumor DNA in plasma of breast cancer patients: clinicopathological correlations. Cancer Research. ,vol. 59, pp. 3251- 3256 ,(1999)
Kurt Miller, Maurice Stroun, Philippe Anker, Ralf Münker, Markus Müller, Hans Krause, Rüdiger Heicappell, Carsten Goessl, Microsatellite Analysis of Plasma DNA from Patients with Clear Cell Renal Carcinoma Cancer Research. ,vol. 58, pp. 4728- 4732 ,(1998)
AndrewJ.G. Simpson, The natural somatic mutation frequency and human carcinogenesis. Advances in Cancer Research. ,vol. 71, pp. 209- 240 ,(1997) , 10.1016/S0065-230X(08)60100-1
David Sidransky, Susan Booker, C. Rahj Robinson, Stanley R. Hamilton, Kenji Hibi, Jin Jen, Li Wu, Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients Cancer Research. ,vol. 58, pp. 1405- 1407 ,(1998)
R. H. Hruban, D. Sidransky, H. Nawroz, P. Van Der Riet, W. Koch, J. M. Ruppert, Allelotype of Head and Neck Squamous Cell Carcinoma Cancer Research. ,vol. 54, pp. 1152- 1155 ,(1994)
JK Field, H Kiaris, P Howard, ED Vaughan, DA Spandidos, AS Jones, Microsatellite instability in squamous cell carcinoma of the head and neck. British Journal of Cancer. ,vol. 71, pp. 1065- 1069 ,(1995) , 10.1038/BJC.1995.205
Roberta A.U. Bevilacqua, Diana N. Nunes, Maurice Stroun, Philippe Anker, The use of genetic instability as a clinical tool for cancer diagnosis. Seminars in Cancer Biology. ,vol. 8, pp. 447- 453 ,(1998) , 10.1006/SCBI.1998.0122
G. M. Hampton, A. A. Larson, R. N. Baergen, R. L. Sommers, S. Kern, W. K. Cavenee, Simultaneous assessment of loss of heterozygosity at multiple microsatellite loci using semi-automated fluorescence-based detection: subregional mapping of chromosome 4 in cervical carcinoma. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 6704- 6709 ,(1996) , 10.1073/PNAS.93.13.6704
L Cawkwell, SM Bell, FA Lewis, MF Dixon, GR Taylor, P Quirke, Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology. British Journal of Cancer. ,vol. 67, pp. 1262- 1267 ,(1993) , 10.1038/BJC.1993.236